Gene information
Official symbol HMGCR
Official full name 3-hydroxy-3-methylglutaryl-CoA reductase
Gene type protein-coding gene
Chromosome5q13.3
Resources
Entrez Gene 3156
HGNC HGNC:5006
Ensembl ENSG00000113161
Vega OTTHUMG00000102069
UCSC uc003kdp.4
GO terms: 59 records
GO Description Category LogP Number of genes Detail
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0006066 alcohol metabolic process GO Biological Processes -16.7128396 29 More
GO:0006163 purine nucleotide metabolic process GO Biological Processes -1.90037391 10 More
GO:0006469 negative regulation of protein kinase activity GO Biological Processes -12.6852914 37 More
GO:0006694 steroid biosynthetic process GO Biological Processes -2.61471913 6 More
GO:0006695 cholesterol biosynthetic process GO Biological Processes -3.02599739 4 More
GO:0006720 isoprenoid metabolic process GO Biological Processes -5.01065294 9 More
GO:0006753 nucleoside phosphate metabolic process GO Biological Processes -1.97459133 12 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007611 learning or memory GO Biological Processes -7.55755517 33 More
GO:0007612 learning GO Biological Processes -4.32260958 18 More
GO:0008202 steroid metabolic process GO Biological Processes -19.3229835 29 More
GO:0008203 cholesterol metabolic process GO Biological Processes -19.4799126 22 More
GO:0008306 associative learning GO Biological Processes -3.80327331 12 More
GO:0008610 lipid biosynthetic process GO Biological Processes -6.38047816 23 More
GO:0009117 nucleotide metabolic process GO Biological Processes -2.02959005 12 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0016125 sterol metabolic process GO Biological Processes -19.5624674 23 More
GO:0016126 sterol biosynthetic process GO Biological Processes -2.74134667 4 More
GO:0016491 oxidoreductase activity GO Molecular Functions -14.1519969 39 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0033673 negative regulation of kinase activity GO Biological Processes -12.5521161 39 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043407 negative regulation of MAP kinase activity GO Biological Processes -8.66647370 10 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043409 negative regulation of MAPK cascade GO Biological Processes -13.5471736 35 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044283 small molecule biosynthetic process GO Biological Processes -16.6163676 33 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0046165 alcohol biosynthetic process GO Biological Processes -3.02044097 6 More
GO:0050661 NADP binding GO Molecular Functions -1.63389635 6 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050709 negative regulation of protein secretion GO Biological Processes -12.5236372 21 More
GO:0050890 cognition GO Biological Processes -8.00500082 37 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051224 negative regulation of protein transport GO Biological Processes -11.0190941 26 More
GO:0051348 negative regulation of transferase activity GO Biological Processes -13.2006110 43 More
GO:0055086 nucleobase-containing small molecule metabolic process GO Biological Processes -1.91021091 13 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071901 negative regulation of protein serine/threonine kinase activity GO Biological Processes -13.7044922 29 More
GO:0072521 purine-containing compound metabolic process GO Biological Processes -2.16218573 11 More
GO:1900221 regulation of amyloid-beta clearance GO Biological Processes -7.04725442 6 More
GO:1901615 organic hydroxy compound metabolic process GO Biological Processes -22.7091625 41 More
GO:1901617 organic hydroxy compound biosynthetic process GO Biological Processes -2.99916656 8 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1902652 secondary alcohol metabolic process GO Biological Processes -19.9585075 23 More
GO:1902653 secondary alcohol biosynthetic process GO Biological Processes -3.02599739 4 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903531 negative regulation of secretion by cell GO Biological Processes -17.4034654 36 More
GO:1903828 negative regulation of protein localization GO Biological Processes -8.86943289 30 More
GO:1904950 negative regulation of establishment of protein localization GO Biological Processes -11.4813166 27 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04152 AMPK signaling pathway KEGG Pathway -7.66810818 12 More
hsa04976 Bile secretion KEGG Pathway -3.16953788 6 More
Drug-Gene interaction
view
Related drugs: 19 records
Drug name Interaction type Source PMID View
aspirin TTD view
atorvastatin inhibitor TdgClinicalTrialTENDPharmGKBTTD 1756340115109613154745031881558918332269161038962003158218261733128084851519903126408409127691271574815711752352 view
atorvastatin calcium inhibitor ChemblInteractions view
cerivastatin inhibitor TTD 107401371019377611057870117523521144892511470741 view
cerivastatin sodium inhibitor ChemblInteractions view
crilvastatin TTD view
fluvastatin inhibitor TdgClinicalTrialTENDPharmGKBTTD 175634011881558918332269161038961826173315199031105922351175235219249983 view
fluvastatin sodium inhibitor ChemblInteractions view
laropiprant TTD view
lovastatin inhibitor DTCTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractionsTENDPharmGKBTTD 175634011881558918332269161038961240529312172803123691431826173315199031120825501220410811752352122140632472630619249983 view
pitavastatin inhibitor TdgClinicalTrialTEND 2247290828130659 view
pitavastatin calcium inhibitor ChemblInteractions view
pravastatin inhibitor TdgClinicalTrialTENDPharmGKBTTD 175634012559157218815589183322691129848216103896182617331519903111752352 view
pravastatin sodium inhibitor ChemblInteractions view
rosuvastatin inhibitor TdgClinicalTrialTENDTTD 1253981612773150117723271248120211752352112568471612857511501230 view
rosuvastatin calcium inhibitor ChemblInteractions view
simvastatin inhibitor DTCTdgClinicalTrialChemblInteractionsTENDPharmGKBTTD 1756340118815589183322691251803916103896126771701826173315199031128524531267158111752352166801591243381016128575 view
teriflunomide TTD view
tocotrienol TTD view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NM_000859.3:c.2458-84C>T genomics myocardial infarction[diagnosis] myocardial infarction Iqbal R et al. Mol Biol Rep. 2014
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